ALPHA LIPOIC ACID
Alpha lipoic acid is a fatty acid found naturally inside every cell
in the body. It's needed by the body to produce the energy for our
body's normal functions. Alpha lipoic acid converts glucose (blood
sugar) into energy. Other names for it include lipoic acid, thioctic
acid, and ALA.
Alpha lipoic acid is also an antioxidant, a substance that
neutralizes potentially harmful chemicals called free radicals. What
makes alpha lipoic acid unique is that it functions in water and fat,
unlike the more common antioxidants vitamin C and vitamin E ,and it appears to be able to recycle antioxidants such as vitamin C and glutathione after they have been used up. Glutathione is an important antioxidant that helps the body eliminate potentially
harmful substances. Alpha lipoic acid increases the formation of
glutathione.
Health Benefits of Alpha Lipoic Acid:
1) Peripheral Neuropathy
Peripheral neuropathy can be caused by injury, nutritional deficiencies, chemotherapy or by conditions such as diabetes, Lyme disease, alcoholism, shingles, thyroid disease, and kidney failure. Symptoms can include pain, burning, numbness, tingling, weakness, and itching.
Alpha lipoic acid is thought to work as an antioxidant in both water
and fatty tissue, enabling it to enter all parts of the nerve cell and
protect it from damage.
Preliminary studies suggest that alpha lipoic acid may help. In one
of the largest studies on the use of alpha lipoic acid, 181 people took
600 mg, 1200 mg or 1800 mg of alpha lipoic acid a day or a placebo.
After 5 weeks, alpha lipoic acid improved symptoms. The dose that was
best tolerated while still providing benefit was 600 mg once daily.
2) Brain Function
Alpha lipoic acid can cross the blood-brain barrier, a wall of tiny
vessels and structural cells, and pass easily into the brain. It is
thought to protect brain and nerve tissue by preventing free radical
damage.
3) Age-Related Conditions
As an antioxidant, alpha lipoic acid can neutralize free radicals
which can damage cells. Free radical damage is thought to contribute to
aging and chronic illness.
Other Common Uses:
Alpha lipoic acid has also been suggested for cataracts, glaucoma, multiple sclerosis, burning mouth syndrome, Alzheimer's disease and stroke, but large, well-designed studies are needed to see if it's effective for these conditions.
Sources
Alpha lipoic acid is made by the body and can be found in very small
amounts in foods such as spinach, broccoli, peas, Brewer's yeast,
brussel sprouts, rice bran, and organ meats.
Side Effects
Side effects of alpha lipoic acid may include headache, tingling or a
"pins and needles" sensation, skin rash, or muscle cramps.
There have been a few reports in Japan of a rare condition called
insulin autoimmune syndrome in people using alpha lipoic acid. The
condition causes hypoglycemia and antibodies directed against the body's
own insulin without previous insulin therapy.
The safety of alpha lipoic acid in pregnant or nursing women, children, or people with kidney or liver disease is unknown.
Possible Drug Interactions
Alpha lipoic acid may improve blood sugar control, so people with
diabetes who are taking medication to lower blood sugar, such as
metformin (Glucophage), glyburide (DiaBeta, Glynase), should only take
alpha lipoic acid under the supervision of a qualified health
professional and have their blood sugar levels carefully monitored.
Animal studies indicate that alpha lipoic acid may alter thyroid
hormone levels, so it could theoretically have the same effect in
humans. People taking thyroid medications such as levothyroxine should
be monitored by their healthcare provider.
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